Symphone Sanders, senior adviser and senior spokesman for Deputy President Kamala Harris, is expected to step down by the end of the month, a White House official and four other sources familiar with the matter told NBC News.
His departure will mark the second major exit from Harris' office in recent weeks. Ashley Etienne, vice president of communications, announced last month that she would be leaving in December.
A White House official said on Wednesday that Sanders had "worked honorably" for three years, first as part of President Joe Biden's 2020 campaign and then in the transition team before joining the vice president's office.
The official said the president and vice-president were "grateful" for Sanders' work on behalf of the management and called him a "team player" to be missed.
Sanders' plans beyond the vice president's office were not immediately known.
Politico and CNN have previously reported on Sanders' departure.
While it is not uncommon for White House aides to leave the year to enter a new administration, the departure of two high-level officials comes as Harris struggles to define his role as vice president. In recent weeks, Harris has had to wander through a number of unpopular media outlets that have exposed hard work inside and raised questions about his future as party leader if Biden decides not to run for re-election in 2024.
Sanders has been one of the most outspoken advocates of the vice president, especially on topics such as Harris' work to emigrate to the Northern Triangle. Sanders has repeatedly backtracked on Republican attempts to arrest Harris in the wake of the US-Mexico border crossing.
With both Sanders and Etienne gone, some allies in the vice presidency hope that Harris can use the opportunity to bring in new leadership to help with what they see as the much-needed resettlement in the mid-year election. Some of the partners said 2022 would be an important opportunity for Harris to explain his position to the management and the party as a whole.
It was not immediately clear who would play the key role of communications in the vice president's office. In September, Harris brought in Lorraine Voles and Adam Frankel, two veteran Democrat strategists, to help him with his communication strategy.